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Mentors and Regional Facilitators
| Name | Region | Skills | Interests |
|---|---|---|---|
| Anita Schwartz | Campus Champions | ||
| Michael Blackmon | Campus Champions, ACCESS CSSN | ||
| Brian Haymore | Campus Champions, RMACC, CCMNet | ||
| Kevin Bryan | Campus Champions | ||
| Christina Divoll | Campus Champions, ACCESS CSSN | ||
| Cody Stevens | Campus Champions, CCMNet | ||
| David Liu | CCMNet | ||
| Yu-Chieh Chi | Campus Champions | ||
| Jordan Hayes | Campus Champions | ||
| Juan Vanegas | Northeast | ||
| Kali McLennan | Campus Champions, Great Plains | ||
| Katherine Nelson | Campus Champions, CAREERS, ACCESS CSSN | ||
| James Hutcheson | Campus Champions, ACCESS CSSN | ||
| Justin Oelgoetz | Campus Champions, CCMNet | ||
| Paul Rulis | Campus Champions | ||
| David Reddy | Campus Champions | ||
| Ric Anderson | Campus Champions | ||
| Ruben Lara | Campus Champions | ||
| Steven Kuhlo | TRECIS | ||
| Sathish Srinivasan | ACCESS CSSN | ||
| Trey Breckenridge | Campus Champions |
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Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
Expertise
Kevin Bryan
University of Rhode Island
Programs
Campus Champions
Roles
research computing facilitator
Expertise
David Reddy
University of South Carolina
Programs
Campus Champions
Roles
research computing facilitator, Affinity Group Leader
Expertise
People with Interest
Manas Vishal
University of Massachusetts, Dartmouth
Programs
CAREERS, Northeast, CCMNet
Roles
student-facilitator, CCMNet
Interests
Parameshwaran Pasupathy
Rutgers, the State University of New Jersey
Programs
ACCESS CSSN, CAREERS
Roles
student-facilitator
Interests
Programs
CCMNet
Roles
CCMNet
