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generative-ai

Mentors and Regional Facilitators
Name Region Skills Interests
Aniruddha Maiti ACCESS CSSN, Campus Champions
Devin Bayly ACCESS CSSN, Campus Champions, CCMNet
Brandon Biggs OnDemand
David Liu CCMNet
David Ryglicki
Fan Chen ACCESS CSSN
Feseha Abebe-Akele CCMNet
Mattie Niznik Campus Champions
Dr. Nabeel Alzahrani Campus Champions, CCMNet

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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Aniruddha Maiti

West Virginia State University

Programs

ACCESS CSSN, Campus Champions

Roles

mentor, researcher/educator, cssn

Aniruddha Maiti Profile Picture

Expertise

Feseha Abebe-Akele

Elizabeth City State University

Programs

CCMNet

Roles

mentor, researcher/educator, research computing facilitator, CCMNet

Feseha Abebe-Akele

Expertise

Ana Marija Sokovic

University of Illinois at Chicago

Programs

CCMNet

Roles

CCMNet

Placeholder headshot

Expertise

People with Interest

Devin Bayly

University of Arizona

Programs

ACCESS CSSN, Campus Champions, CCMNet

Roles

research computing facilitator, Affinity Group Leader, CCMNet

User

Interests

Kevin Brandt

South Dakota State University

Programs

Campus Champions, Great Plains, CCMNet

Roles

regional facilitator, representative, research computing facilitator, Affinity Group Leader, CCMNet PM, CCMNet

Photo of Kevin Brandt

Interests

Kevin Brandt

South Dakota State University

Programs

Great Plains, CCMNet

Roles

regional facilitator, Affinity Group Leader, CCMNet

photo of Kevin Brandt

Interests