tuning
Mentors and Regional Facilitators
| Name | Region | Skills | Interests |
|---|---|---|---|
| David Liu | CCMNet | ||
| Jason Wells | ACCESS CSSN, Campus Champions | ||
| Justin Oelgoetz | Campus Champions, CCMNet | ||
| Paul Rulis | Campus Champions | ||
| Ron Rahaman | Campus Champions | ||
| Shaohao Chen | Northeast | ||
| Liwen Shih | Campus Champions, ACCESS CSSN, CCMNet | ||
| Seung Woo Son | Northeast |
Affinity Groups
There are no Affinity Groups associated with this topic. View All Affinity Groups.
Announcements
There are no announcements with this tag. View All Announcements.
Upcoming Events & Trainings
| Title | Date |
|---|---|
| HPC & Data Science Summer Institute 2025 | 8/04/25 |
| HPC & Data Science Summer Institute 2025 | 8/04/25 |
| HPC & Data Science Summer Institute 2025 | 8/04/25 |
Topics from Ask.CI
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Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Fine-tuning LLMs with PEFT and LoRA | Video | faster, optimization, performance-tuning, tuning | Intermediate, Advanced |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
Manas Vishal
University of Massachusetts, Dartmouth
Programs
CAREERS, Northeast, CCMNet
Roles
student-facilitator, CCMNet
Expertise
Expertise
David Liu
Purdue University
Programs
CCMNet
Roles
mentor, researcher/educator, research computing facilitator, CCMNet
Expertise
People with Interest
Gregory Bauer
University of Illinois at Urbana-Champaign
Programs
ACCESS CSSN
Roles
research computing facilitator, Affinity Group Leader, Consultant
Interests
Widodo Samyono
Jarvis Christian College
Programs
Campus Champions, CCMNet
Roles
researcher/educator, research computing facilitator, CCMNet
Interests
